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202145
India
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Department of Biotechnology (DBT), Ministry of Science & Technology, Government of India approved project “Design and Synthesis of Potent analogues of Peroxisome Proliferator activated gamma receptor agonist by allosteric modulation study”

Duration- 02 years
Date of Sanction- 22 July 15
Principal Investigator- Mr. Ram Babu Tripathi
Amount- 5.37 Lakh

 

SUMMARY OF THE PROJECT
Bioinformatics and computational biology is interdisciplinary field that applies the techniques of computer science, applied mathematics and statistics to address biological problems. Allosteric modulation help in identifying drug targets via bioinformatics tools. They can be used to analyze the target structure for possible binding site, generate candidate molecules, and check for their drug likeness. Docking of these molecules with the target and rank them according to their binding affinity. Further, optimize the molecules to improve binding characteristics. Development of peroxisome proliferators’ gamma ( agonist molecules using combination of bioinformatics tools like QSAR and docking provides a faster, cost effective and reliable methodology. These tools have now become integral part of lead discovery, SAR development and lead optimization. In this project, it is planned to develop new pharmacological approaches to treat levodopa-induced dyskinesia (LID) in a pre-clinical model of Parkinson’s disease (PD).